The International Society of Cryosurgery (I.S.C.) has commenced its activity in 1974 to promote lasting medical education in the field of cryosurgery, from both an experimental and a clinical point of view.

The overall aim of the I.S.C. is to continue developing and expanding the use of cryosurgery around the world. The society has its headquarters in via Fabio Severo 3, 34133 Trieste, Italy. The society corresponds with members world-wide.

Membership is open to anyone who has a professional interest in research and education in the fields of cryosurgery, cryobiology, cryopreservation, and other disciplines related to the use of low temperatures in medicine.

A major world congress with a wide-ranging scientific programme covering all areas of cryosurgery and cryobiology is held every second year (autumn) in a different continent. The Society also grants special awards to young researchers for significant achievements.

Besides its main meeting, ISC has taken up regional activities and meetings in Europe, Mediterranean, Asia, Australasia & Pacific, North America, South America and Africa. 
These meetings are organised by members of the ISC Board who are stationed in the respective continent. So far they included "Cryosurgery in the Americas" (Montreal),  "Cryosurgery in the treatment of cancer" (Corfu) and the 4th annual meeting of the Association of British and Irish Cryosurgery (ABIC) in Crewe.